Choosing Between PRF and PRP for Med Spa Under-Eye Treatments

We often see clients confused by the technical differences between PRP and PRF when addressing hollow tear troughs. While both involve autologous blood concentrates, we prefer Platelet-Rich Fibrin for the delicate under-eye area because it is processed at a lower centrifuge speed. This slower spin preserves more leukocytes and mesenchymal stem cells while creating a natural fibrin matrix that acts as a temporary scaffold. Unlike PRP, which releases its growth factors in a sudden burst, PRF provides a sustained release over several days. From an operational standpoint, we find that PRF offers a more significant clinical improvement in skin quality and volume without the need for synthetic additives like anticoagulants. We prioritize PRF because the resulting clot allows for longer-lasting tissue regeneration in the periorbital region, leading to higher patient satisfaction and better long-term retention rates for our aesthetic practices.